Located in a splendid panoramic position, the Parish Church of Polpenazze, dedicated to the Nativity of the Virgin Mary, is a church dating back to the second half of the 16th century, although the authorisation for its erection was still granted in 1400 by Pope Pius II. The church has a single hall terminating in a polygonal presbytery and is characterised by the presence of shallow but richly decorated bays, such as the ceiling and apse, with frescoes and paintings attributable to Andrea Bertanza, Pietro Marone and Graziano Cossali. At the end of the 19th century, architect Tagliaferri decided to redesign the façade of the parish church according to Baroque-style architectural schemes. It now consists of a sloping façade, characterised by fluted pilasters in the upper part and a large window framed by sinuous decorations. In the part below is a projecting portico surmounted by a balcony, open to the square, thanks to the presence of a serliana, an architectural element composed of a round arch flanked by two openings surmounted by architraves and composed of columns, widely theorised by Sebastiano Serlio and brought to its maximum diffusion by Andrea Palladio. The organ is considered one of the most important in Valtenesi dating back to 1894 and composed of pipes dating back to the 16th and 18th centuries, the work of Pacifico Inzoli.